O-30: Novel Interventions to Reduce ReInfection in Women with Chlamydia: A Randomised-Controlled Trial

Background: To determine if postal testing kits (PTK) and patient delivered partner therapy (PDPT) for managing sexual partners of women with Chlamydia tracho-matis, reduce re-infection rates in women, compared to partner notification by patient referral. Materials and Methods: Three hundred and thirty women testing positive for chlamydia, at clinics for genitourinary medicine, family planning and ter- mination of pregnancy in Edinburgh, were randomized to one of three partner interventions: patient referral, PTK ( partners post urine for testing) or PDPT (1 g azithromycin for partners). Women submitted urine for chlamydia testing every 3 months. The primary outcome was reinfection assessed as time to first positive result by the Cox proportional hazard regression. The proportion of partners tested or treated with each intervention was determined.Results: Out of 330 women, 215 (65%) were retested over 12 months. There were 32 of 215 women (15%) who retested positive (7, 15 and 10 women from the patient referral, PTK and PDPT groups, respectively). There was no significant difference in re-infection between PDPT versus patient referral (HR 1.32, 95% CI 0.50 – 3.56), PTK versus patient referral (HR 2.35, 95% CI 0.94 – 5.88) or PDPT versus PTK (HR 0.55, 95% CI 0.24 – 1.24). There was no significant difference in the proportion of partners confirmed tested/treated between the patient referral (34%) and PTK (41%, p=0.32) or PDPT (42%, p=0.28) groups. Conclusion: PTK and PDPT do not reduce re-infection rates in women with chlamydia compared with patient referral. However, PDPT may offer other advantages such as simplicity and cost compared with patient referral.